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Nicholas D Smith Selected Research

4- ((2- cyclobutyl- 1H- imidazo(4,5- b)pyrazin- 1- yl)methyl)- 7,8- difluoroquinolin- 2(1H)- one

2/2011Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases.
11/2010Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOS dimerization inhibitors that are orally active in pain models.
5/2009Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.

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Nicholas D Smith Research Topics

Disease

8Neoplasms (Cancer)
01/2019 - 05/2008
7Breast Neoplasms (Breast Cancer)
01/2019 - 06/2015
4Pain (Aches)
02/2011 - 05/2009
4Insulin Resistance
12/2008 - 01/2003
3Hyperthyroidism
12/2008 - 06/2002
3Starvation
12/2008 - 06/2002
2Prostatic Neoplasms (Prostate Cancer)
03/2012 - 05/2008
2Neuralgia (Stump Neuralgia)
11/2010 - 05/2009
1Pruritus (Itching)
01/2021
1Alcoholic Fatty Liver
01/2021
1Scotoma (Scintillating Scotoma)
09/2016
1Glaucoma
12/2015
1Inflammation (Inflammations)
01/2012
1Hyperalgesia
02/2011
1Edema (Dropsy)
02/2011
1Endotoxemia
07/2009
1Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous)
05/2008
1Hyperglycemia
12/2006
1Brain Ischemia (Cerebral Ischemia)
07/2005
1Hyperinsulinism (Hyperinsulinemia)
02/2004
1Glucose Intolerance
09/2003

Drug/Important Bio-Agent (IBA)

7Estrogen ReceptorsIBA
01/2019 - 06/2015
6TamoxifenFDA LinkGeneric
01/2019 - 06/2015
5Insulin (Novolin)FDA Link
12/2008 - 06/2002
4Formaldehyde (Formol)FDA Link
02/2011 - 05/2009
4Glucose (Dextrose)FDA LinkGeneric
12/2008 - 01/2003
4PPAR alphaIBA
12/2008 - 06/2002
33- (4- (2- (2- chloro- 4- fluorophenyl)- 1- (1H- indazol- 5- yl)but- 1- en- 1- yl)phenyl)acrylic acidIBA
01/2019 - 06/2015
34- ((2- cyclobutyl- 1H- imidazo(4,5- b)pyrazin- 1- yl)methyl)- 7,8- difluoroquinolin- 2(1H)- oneIBA
02/2011 - 05/2009
3KD 5170IBA
12/2008 - 05/2008
3LipidsIBA
12/2008 - 02/2003
3pirinixic acidIBA
02/2003 - 06/2002
2IndazolesIBA
01/2019 - 11/2015
2Aromatase InhibitorsIBA
01/2018 - 06/2015
2Estrogen Receptor alphaIBA
01/2018 - 06/2015
2Nitric Oxide (Nitrogen Monoxide)FDA Link
01/2012 - 02/2011
2Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
02/2011 - 05/2009
2Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA
02/2011 - 11/2010
2QuinolonesIBA
11/2010 - 05/2009
2Peroxisome Proliferator-Activated Receptors (PPAR)IBA
12/2008 - 01/2003
2Histones (Histone)IBA
12/2008 - 06/2008
2Histone Deacetylase InhibitorsIBA
12/2008 - 05/2008
2Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA
02/2004 - 09/2003
2Fatty Acids (Saturated Fatty Acids)IBA
02/2004 - 06/2002
2Proteins (Proteins, Gene)FDA Link
02/2003 - 06/2002
1oxidized low density lipoproteinIBA
01/2021
1LDL CholesterolIBA
01/2021
1FXR agonist MET409IBA
01/2021
1BenzopyransIBA
01/2018
1Androgen Receptors (Androgen Receptor)IBA
03/2012
1apalutamideIBA
03/2012
1Androgen Antagonists (Antiandrogens)IBA
03/2012
1Biological ProductsIBA
01/2012
1Nitric Oxide Synthase (NO Synthase)IBA
01/2012
1EnzymesIBA
01/2012
1phenylbenzoquinoneIBA
02/2011
1Celecoxib (Celebrex)FDA Link
02/2011
1Duloxetine Hydrochloride (Cymbalta)FDA Link
02/2011
1CarrageenanIBA
02/2011
1Gabapentin (Neurontin)FDA LinkGeneric
02/2011
1Capsaicin (Zostrix)FDA Link
02/2011
1Pregabalin (Lyrica)FDA Link
02/2011
1benzimidazoleIBA
11/2010
1N- (3- chlorophenyl)- N- ((8- fluoro- 2- oxo- 1,2- dihydroquinolin- 4- yl)methyl)- 4- methylthiazole- 5- carboxamideIBA
07/2009
1Thyroid Hormone Receptors (Thyroid Hormone Receptor)IBA
12/2008
1Thyroid HormonesIBA
12/2008
1Triiodothyronine (Liothyronine)FDA LinkGeneric
12/2008
1CarbohydratesIBA
12/2008
1Histone Deacetylases (Histone Deacetylase)IBA
05/2008
1Docetaxel (Taxotere)FDA Link
05/2008
1VorinostatFDA Link
05/2008
1Dexamethasone (Maxidex)FDA LinkGeneric
12/2006
1ProdrugsIBA
07/2005
1Choline (Choline Chloride)IBA
07/2005
1Fish OilsIBA
02/2004
1Pyruvate Dehydrogenase Acetyl-Transferring KinaseIBA
06/2002
1Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)IBA
06/2002
1pyruvate dehydrogenase kinase 4IBA
06/2002
1Protein Isoforms (Isoforms)IBA
06/2002

Therapy/Procedure

3Therapeutics
01/2018 - 06/2015
2Telescopes
09/2016 - 12/2015
2Carbohydrate-Restricted Diet (Low Carbohydrate Diet)
12/2008 - 06/2002
1Castration
03/2012
1Ligation
02/2011
1Oral Administration
07/2009
1Intravenous Administration
07/2005
1Subcutaneous Injections
06/2002